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Ichino, Lucia; Boone, Brandon A; Strauskulage, Luke; Harris, C Jake; Kaur, Gundeep; Gladstone, Matthew A; Tan, Maverick; Feng, Suhua; Jami-Alahmadi, Yasaman; Duttke, Sascha H; Wohlschlegel, James A; Cheng, Xiaodong; Redding, Sy; Jacobsen, Steven E
Science (American Association for the Advancement of Science), 06/2021, Letnik: 372, Številka: 6549Journal Article
DNA methylation is associated with transcriptional repression of eukaryotic genes and transposons, but the downstream mechanism of gene silencing is largely unknown. Here we describe two methyl-CpG binding domain proteins, MBD5 and MBD6, that are recruited to chromatin by recognition of CG methylation, and redundantly repress a subset of genes and transposons without affecting DNA methylation levels. These methyl-readers recruit a J-domain protein, SILENZIO, that acts as a transcriptional repressor in loss-of-function and gain-of-function experiments. J-domain proteins often serve as co-chaperones with HSP70s. Indeed, we found that SILENZIO's conserved J-domain motif was required for its interaction with HSP70s and for its silencing function. These results uncover an unprecedented role of a molecular chaperone J-domain protein in gene silencing downstream of DNA methylation.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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