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Liu, Yuxia; Du, Fuqiang; Lin, Weizhen; Tu, Tiecheng; Li, Wenxin; Lin, Nianyun
Progress in Natural Science/Progress in natural science, 2008, Letnik: 18, Številka: 4Journal Article
By ESR spin elimination and photocleavage assay, the mechanisms of one-electron oxidation damage of oligonucleotides by excited triplet state of riboflavin （Rb） have been elucidated. The results demonstrate that Rb, an endogenous photosensitizer, is capable of cleav- ing single-stranded telomeric overhang and the template region of telomerase RNA under UVA irradiation, resulting in blocking of reverse transcription of telomeric DNA which leads to the apoptosis of cancer cells ultimately. ~ 2007 National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Limited and Science in China Press. All rights reserved.
