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  • Large-scale phenotyping of ...
    Myint, Anthony; White, Cory H.; Ohmen, Jeffrey D.; Li, Xin; Wang, Juemei; Lavinsky, Joel; Salehi, Pezhman; Crow, Amanda L.; Ohyama, Takahiro; Friedman, Rick A.

    Hearing research, 02/2016, Letnik: 332
    Journal Article

    A cornerstone technique in the study of hearing is the Auditory Brainstem Response (ABR), an electrophysiologic technique that can be used as a quantitative measure of hearing function. Previous studies have published databases of baseline ABR thresholds for mouse strains, providing a valuable resource for the study of baseline hearing function and genetic mapping of hearing traits in mice. In this study, we further expand upon the existing literature by characterizing the baseline ABR characteristics of 100 inbred mouse strains, 47 of which are newly characterized for hearing function. We identify several distinct patterns of baseline hearing deficits and provide potential avenues for further investigation. Additionally, we characterize the sensitivity of the same 100 strains to noise exposure using permanent thresholds shifts, identifying several distinct patterns of noise-sensitivity. The resulting data provides a new resource for studying hearing loss and noise-sensitivity in mice. •We conducted a superficial screening study for hearing function in 100 inbred strains of mice.•Several distinct patterns of baseline hearing impairment are observed, and possible avenues of research are discussed.•We also characterize the sensitivity of the same 100 strains to damaging levels of noise.•Several distinct patterns of noise-sensitivity are observed, and possible avenues of research are discussed.•The combined dataset is made available for general use.