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Voss, William N; Hou, Yixuan J; Johnson, Nicole V; Delidakis, George; Kim, Jin Eyun; Javanmardi, Kamyab; Horton, Andrew P; Bartzoka, Foteini; Paresi, Chelsea J; Tanno, Yuri; Chou, Chia-Wei; Abbasi, Shawn A; Pickens, Whitney; George, Katia; Boutz, Daniel R; Towers, Dalton M; McDaniel, Jonathan R; Billick, Daniel; Goike, Jule; Rowe, Lori; Batra, Dhwani; Pohl, Jan; Lee, Justin; Gangappa, Shivaprakash; Sambhara, Suryaprakash; Gadush, Michelle; Wang, Nianshuang; Person, Maria D; Iverson, Brent L; Gollihar, Jimmy D; Dye, John; Herbert, Andrew; Finkelstein, Ilya J; Baric, Ralph S; McLellan, Jason S; Georgiou, George; Lavinder, Jason J; Ippolito, Gregory C
Science, 06/2021, Letnik: 372, Številka: 6546Journal Article
The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are unknown. Proteomic deconvolution of the IgG repertoire to the spike glycoprotein in convalescent subjects revealed that the response is directed predominantly (>80%) against epitopes residing outside the receptor-binding domain (RBD). In one subject, just four IgG lineages accounted for 93.5% of the response, including an N-terminal domain (NTD)-directed antibody that was protective against lethal viral challenge. Genetic, structural, and functional characterization of a multi-donor class of "public" antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. These data show that "public" NTD-directed and other non-RBD plasma antibodies are prevalent and have implications for SARS-CoV-2 protection and antibody escape.
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in: SICRIS
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