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Dickey, Jennifer S; Redon, Christophe E; Nakamura, Asako J; Baird, Brandon J; Sedelnikova, Olga A; Bonner, William M
Chromosoma, 12/2009, Letnik: 118, Številka: 6Journal Article
Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed γ-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of γ-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that γ-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.
