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Solomon, Benjamin D; Hsieh, Chyi-Song
The Journal of immunology (1950), 11/2016, Letnik: 197, Številka: 9Journal Article
Foxp3 retinoic acid-related orphan receptor (ROR)γt T cells have recently been characterized as an immunoregulatory population highly enriched in the colon lamina propria. However, their developmental origin and relationship to RORγt regulatory T and Th17 cells remain unclear. In this study, we use a fixed TCRβ system to show that the TCR repertoire of the Foxp3 RORγt population is mostly distinct compared with other colonic T cell subsets. However, of these TCRs, a fraction is also found in the Th17 subset, suggesting that TCR repertoire overlap may contribute to the reported ability of Foxp3 RORγt cells to regulate Th17 immunity. Naive transgenic T cells expressing a Foxp3 RORγt -restricted TCR first acquire a Foxp3 RORγt phenotype before coexpressing RORγt, suggesting that Foxp3 RORγt cell development can occur via an RORγt regulatory T cell intermediate.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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