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Tlemsani, Camille; Heske, Christine M.; Elloumi, Fathi; Pongor, Lorinc; Khandagale, Prashant; Varma, Sudhir; Luna, Augustin; Meltzer, Paul S.; Khan, Javed; Reinhold, William C.; Pommier, Yves
iScience, 06/2024, Letnik: 27, Številka: 6Journal Article
Sarcomas are a diverse group of rare malignancies composed of multiple different clinical and molecular subtypes. Due to their rarity and heterogeneity, basic, translational, and clinical research in sarcoma has trailed behind that of other cancers. Outcomes for patients remain generally poor due to an incomplete understanding of disease biology and a lack of novel therapies. To address some of the limitations impeding preclinical sarcoma research, we have developed Sarcoma_CellMinerCDB, a publicly available interactive tool that merges publicly available sarcoma cell line data and newly generated omics data to create a comprehensive database of genomic, transcriptomic, methylomic, proteomic, metabolic, and pharmacologic data on 133 annotated sarcoma cell lines. The reproducibility, functionality, biological relevance, and therapeutic applications of Sarcoma_CellMinerCDB described herein are powerful tools to address and generate biological questions and test hypotheses for translational research. Sarcoma_CellMinerCDB (https://discover.nci.nih.gov/SarcomaCellMinerCDB) aims to contribute to advancing the preclinical study of sarcoma. Display omitted •Sarcoma_CellMinerCDB merges publicly available and new sarcoma cell line data•It includes reproducible genomic and pharmacologic data for 133 sarcoma cell lines•It is a novel comprehensive resource including the methylome of sarcoma cell lines•Its multi-functionality can be used to identify new therapeutic targets for sarcoma Cell biology; Cancer systems biology; Cancer; Genomics; Proteomics ; Transcriptomics
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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