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Machushynets, Nataliia V; Elsayed, Somayah S; Du, Chao; Siegler, Maxime A; de la Cruz, Mercedes; Genilloud, Olga; Hankemeier, Thomas; van Wezel, Gilles P
Scientific reports, 02/2022, Letnik: 12, Številka: 1Journal Article
Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less than 5% of the chemical space of natural products has been mined. Here, we describe the discovery of the novel actinomycins L and L produced by Streptomyces sp. MBT27, via application of metabolic analysis and molecular networking. Actinomycins L and L are diastereomers, and the structure of actinomycin L was resolved using NMR and single crystal X-ray crystallography. Actinomycin L is formed via spirolinkage of anthranilamide to the 4-oxoproline moiety of actinomycin X prior to the condensation of the actinomycin halves. Such a structural feature has not previously been identified in naturally occurring actinomycins. Adding anthranilamide to cultures of the actinomycin X producer Streptomyces antibioticus, which has the same biosynthetic gene cluster as Streptomyces sp. MBT27, resulted in the production of actinomycin L. This supports a biosynthetic pathway whereby actinomycin L is produced from two distinct metabolic routes, namely those for actinomycin X and for anthranilamide. Actinomycins L and L showed significant antimicrobial activity against Gram-positive bacteria. Our work shows how new molecules can still be identified even in the oldest of natural product families.
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