E-viri
Recenzirano
Odprti dostop
-
Glubb, Dylan M; Amant, Frederic; Annibali, Daniela; Ashton, Katie; Attia, John; Auer, Paul L; Beckmann, Matthias W; Black, Amanda; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Buchanan, Daniel D; Burwinkel, Barbara; Chanock, Stephen J; Chen, Chu; Chen, Maxine M; Cheng, Timothy H T; Clarke, Christine L; Clendenning, Mark; Cook, Linda S; Couch, Fergus J; Czene, Kamila; Day, Felix; Dennis, Joe; Depreeuw, Jeroen; Dörk, Thilo; Dowdy, Sean C; Dürst, Matthias; Ekici, Arif B; Fasching, Peter A; Fridley, Brooke L; Friedenreich, Christine M; Fung, Jenny; Gaudet, Mia M; Giles, Graham G; Goode, Ellen L; Gorman, Maggie; Haiman, Christopher A; Hankison, Susan E; Healey, Catherine S; Hein, Alexander; Hillemanns, Peter; Hodgson, Shirley; Hoivik, Erling A; Holliday, Elizabeth G; Jones, Angela; Krakstad, Camilla; Lambrechts, Diether; Lindblom, Annika; Lissowska, Jolanta; Long, Jirong; Lu, Lingeng; Magliocco, Anthony M; Martin, Lynn; Meindl, Alfons; Michailidou, Kyriaki; Milne, Roger L; Mints, Miriam; Nassir, Rami; Orlow, Irene; Otton, Geoffrey; Palles, Claire; Perry, John R B; Prescott, Jennifer; Proietto, Tony; Rebbeck, Timothy R; Risch, Harvey A; Rogers, Peter A W; Rübner, Matthias; Runnebaum, Ingo; Sacerdote, Carlotta; Sarto, Gloria E; Schumacher, Fredrick; Setiawan, V Wendy; Sheng, Xin; Shu, Xiao-Ou; Southey, Melissa C; Swerdlow, Anthony J; Tham, Emma; Trovik, Jone; Turman, Constance; Tyrer, Jonathan P; Vachon, Celine; Vanderstichele, Adriaan; Wang, Zhaoming; Webb, Penelope M; Wentzensen, Nicolas; Werner, Henrica M J; Winham, Stacey J; Xia, Lucy; Yang, Hannah P; Yu, Herbert; Zheng, Wei; Pharoah, Paul D P; Kraft, Peter; De Vivo, Immaculata; Tomlinson, Ian; Easton, Douglas F; Spurdle, Amanda B; Thompson, Deborah J
Nature communications, 08/2018, Letnik: 9, Številka: 1Journal Article
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.