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Lee, Quintin; Padula, Matthew P; Pinello, Natalia; Williams, Simon H; O'Rourke, Matthew B; Fumagalli, Marcilio Jorge; Orkin, Joseph D; Song, Renhua; Shaban, Babak; Brenner, Ori; Pimanda, John E; Weninger, Wolfgang; Souza, William Marciel de; Melin, Amanda D; Wong, Justin J-L; Crim, Marcus J; Monette, Sébastien; Roediger, Ben; Jolly, Christopher J
PLoS pathogens, 01/2020, Letnik: 16, Številka: 1Journal Article
Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.
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in: SICRIS
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