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Rivier, Jean E; Rivier, Catherine L
Frontiers in neuroendocrinology, 04/2014, Letnik: 35, Številka: 2Journal Article
Highlights • CRFs are mediators of gut, heart, skin, immune system and CNS homeostasis. • First antagonist α-helical CRF(9–41) is potent in the brain, less though in the periphery. • CRF antagonists will likely play a major role in stress-related diseases. • Astressin2 -B was designed to be a CRFR2 selective long acting antagonist. • Stressin1 was designed to be a CRFR1 selective agonist.
