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Jaroszewicz, Jerzy; Kowalska, Justyna; Pawłowska, Małgorzata; Rogalska, Magdalena; Zarębska-Michaluk, Dorota; Rorat, Marta; Lorenc, Beata; Czupryna, Piotr; Sikorska, Katarzyna; Piekarska, Anna; Dworzańska, Anna; Zaleska, Izabela; Mazur, Włodzimierz; Kozielewicz, Dorota; Kłos, Krzysztof; Podlasin, Regina; Angielski, Grzegorz; Oczko-Grzesik, Barbara; Figlerowicz, Magdalena; Szetela, Bartosz; Bolewska, Beata; Frańczak-Chmura, Paulina; Flisiak, Robert; Tomasiewicz, Krzysztof
Cancers, 09/2022, Letnik: 14, Številka: 19Journal Article
Data on the use of remdesivir, the first antiviral agent against SARS-CoV-2, are limited in oncologic patients. We aimed to analyze contributing factors for mortality in patients with malignancies in the real-world CSOVID-19 study. In total, 222 patients with active oncological disorders were selected from a nationwide COVID-19 study of 4890 subjects. The main endpoint of the current study was the 28-day in-hospital mortality. Approximately half of the patients were male, and the majority had multimorbidity (69.8%), with a median age of 70 years. Baseline SpO2 < 85% was observed in 25%. Overall, 59 (26.6%) patients died before day 28 of hospitalization: 29% due to hematological, and 20% due to other forms of cancers. The only factor increasing the odds of death in the multivariable model was eGFR < 60 mL/min/m2 (4.621, p = 0.02), whereas SpO2 decreased the odds of death at baseline (0.479 per 5%, p = 0.002) and the use of remdesivir (0.425, p = 0.03). This study shows that patients with COVID-19 and malignancy benefit from early remdesivir therapy, resulting in a decrease in early mortality by 80%. The prognosis was worsened by low glomerular filtration rate and low peripheral oxygen saturation at baseline underlying the role of kidney protection and early hospitalization.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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