•Conceptualises the idea of e-lienation as a specific form of alienation in ICT-enabled tourism.•Combines philosophic questions of meaning, sociological theory and empirical research.•Demonstrates the meanings of e-lienation, its dimensions, causes, consequences and strategies of resistance. The concept of alienation was adapted to tourism by MacCannell who identified it as a key feature of modernity and a strong driver of tourism where tourists seek to reconnect to authentic places and selves. Meanwhile the post-modern world has witnessed a revolution in Information and Communication Technology (ICT) especially in the realm of smart tourism where its advocates talk eagerly of the internet of everything. Such a totalising prospect demands serious review and this article fills a critical gap by conceptualising the idea of e-lienation as a specific form of alienation in ICT-enabled tourism. It combines philosophic questions of meaning, sociological theory and empirical research to demonstrate the meanings of e-lienation, its dimensions, causes, consequences and strategies of resistance.