E-viri
PDF
Recenzirano
Odprti dostop
-
Murphy, Michael P.; O’Neill, Luke A.J.
Cell, 08/2018, Letnik: 174, Številka: 4Journal Article
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role. The metabolites succinate and itaconate have emerged as key signaling molecules linking mitochondrial function to the rest of the cell across several areas of cell function.
