E-viri
Recenzirano
-
Schoepfer, A. M.; Schaffer, T.; Seibold‐schmid, B.; Müller, S.; Seibold, F.
Neurogastroenterology and motility, October 2008, Letnik: 20, Številka: 10Journal Article
One of the several possible causes of irritable bowel syndrome (IBS) is thought to be low‐grade mucosal inflammation. Flagellin, the primary structural component of bacterial flagellae, was shown in inflammatory bowel disease patients to activate the innate and adaptive immunity. It has not yet been conclusively established if IBS patients show reactivity to luminal antigens. In 266 patients 112 IBS, 61 Crohn’s disease (CD), 50 ulcerative colitis (UC) and 43 healthy controls (HC), we measured antibodies to flagellin (FAB, types A4‐Fla2 and Fla‐X), anti‐Saccharomyces cerevisiae antibodies (ASCA) (both ELISA), antipancreas antibodies (PAB) and perinuclear antineutrophil cytoplasmatic antibodies (p‐ANCA) (both IF). All IBS patients had normal fecal calprotectin (mean 21 μg mL−1, SD 6.6) and fulfilled the ROME II criteria. Frequencies of antibodies in patients with IBS, CD, UC and HC, respectively, are as follows (in per cent): antibodies against A4‐Fla2: 29/48/8/7; antibodies against Fla‐X: 26/52/10/7; ASCA: 6/59/0/2; p‐ANCA: 0/10/52/0; and PAB: 0/28/0/0. Antibodies against A4‐Fla2 and Fla‐X were significantly more frequent in IBS patients than in HC (P = 0.004 and P = 0.009). Antibodies to A4‐Fla2 and Fla‐X were significantly more frequent in IBS patients with antecedent gastroenteritis compared to non‐postinfectious IBS patients (P = 0.002 and P = 0.012). In contrast to ASCA, PAB and p‐ANCA, antibodies against A4‐Fla2 and Fla‐X were found significantly more often in IBS patients, particularly in those with postinfectious IBS, compared to HC. This observation supports the concept that immune reactivity to luminal antigens has a putative role in the development of IBS, at least in a subset of patients.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.