Thermal-infrared measurements of asteroids, satellites, and distant minor bodies are crucial for deriving the objects’ sizes, albedos, and in some cases, also the thermophysical properties of the surface material. Depending on the available measurements and auxiliary data, such as visual light curves, spin and shape information, or direct size measurements from occultations or high-resolution imaging techniques, a range of simple to complex thermal models are applied to achieve specific science goals. However, testing these models is often a difficult process and the uncertainties of the derived parameters are not easy to estimate. Here, we make an attempt to verify a widely accepted thermophysical model (TPM) against unique thermal infrared (IR), full-disk, and well-calibrated measurements of the Moon. The data were obtained by the High-resolution InfraRed Sounder (HIRS) instruments on board a fleet of Earth weather satellites that serendipitously scan the surface of the Moon. We found 22 Moon intrusions, taken in 19 channels between 3.75 μm and 15.0 μm, and over a wide phase angle range from −73.1° (waxing Moon) to +73.8° (waning Moon). These measurements include the entire Moon in a single pixel, seen almost simultaneously in all bands. The HIRS filters are narrow and outside the wavelength regime of the Christiansen feature. The similarity between these Moon data and typical asteroid spectral-IR energy distributions allows us to benchmark the TPM concepts and to point out problematic aspects. The TPM predictions match the HIRS measurements within 5% (10% at the shortest wavelengths below 5 μm) when using the Moon’s known properties (size, shape, spin, albedo, thermal inertia, roughness) in combination with a newly established wavelength-dependent hemispherical emissivity. In the 5–7.5 μm and in the 9.5–11 μm ranges, the global emissivity model deviates considerably from the known lunar sample spectra. Our findings will influence radiometric studies of near-Earth and main-belt asteroids in cases where only short-wavelength data (from e.g., NEOWISE, the warm Spitzer mission, or ground-based M -band measurements) are available. The new, full-disk IR Moon model will also be used for the calibration of IR instrumentation on interplanetary missions (e.g., for Hayabusa-2) and weather satellites.