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He, Bing; Xu, Weifeng; Santini, Paul A; Polydorides, Alexandros D; Chiu, April; Estrella, Jeannelyn; Shan, Meimei; Chadburn, Amy; Villanacci, Vincenzo; Plebani, Alessandro; Knowles, Daniel M; Rescigno, Maria; Cerutti, Andrea
Immunity (Cambridge, Mass.), 06/2007, Letnik: 26, Številka: 6Journal Article
Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective immunoglobulin A (IgA) antibodies. The distal intestine contains IgA2, which is more resistant to bacterial proteases than is IgA1. The mechanism by which B cells switch from IgM to IgA2remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA2class switching in B cells, including IgA1-expressing B cells arriving from mucosal follicles, through a CD4+T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA2class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA2responses.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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