Lomonosov is the founder of secular education in Russia. The long process of forming the educational principles that created the basis for scientific development and the training of academic personnel resulted in the creation of Moscow University. The university under Lomonosov's plan embodied the unity of natural science and humanities, elimination of theology and the secular education system, training of national academic personnel, combining education and upbringing, implementation of the principles of self-government. This article considers the outstanding ideas of the scientist and thinker in terms of their interrelationship, interdependence, and mutual influence, thereby offering a holistic view of this Russian scientist's work. The methods used in this study are based on philosophical research traditions. The findings of this research can be used to advance research on the relationship between science and philosophical knowledge, both in the scientist's activity and in the education system.