•Ductile fracture of X80 pipeline steel is investigated experimentally and numerically.•Three fracture modes are observed in the experiments.•Parallel computations corresponding to the experiments are conducted.•The newly proposed model can provide relatively more stable and accurate prediction in fracture strain. This study pays attention to the ductile fracture of X80 pipeline steel using both experimental and numerical approaches. First, nineteen experimental cases are tested, consisting of the normalized uniaxial tension, the plain strain tension, pure shear, and shear plus tension/compression. Three fracture modes are observed throughout the experiments. A hybrid testing-FE method is applied to determine the post-necking strain hardening curve of the X80 pipeline steel. Then, parallel computations are conducted in the Abaqus to obtain ductile fracture parameters. The simulated results indicate that the determined strain hardening curve has applicability for all experiments. According to the ductile fracture parameters, three models, viz. the Hosford-Coulomb model, the DF2016 model, and a newly proposed model, are calibrated based on the hold-out strategy. Fracture prediction of the X80 pipeline steel is conducted by the three calibrated models. The results show that the newly proposed model outperforms the other two in terms of stability and accuracy.