The role of hot or wind pressing forming a pressure difference between the indoor and out-door of the building envelop, the unorganized infiltration air will flow into rooms. Indoor and outdoor temperature, outdoor wind direction and speed have an impact on the infiltration air volume. There are multiple aisles connecting the outdoor space and the station hall, leading to a large amount of outdoor air into the station. In this paper, the measurement of infiltration air volume and regional temperature in railway station was performed in Wuhan. The software ContamW was used to simulate the ventilation paths and the infiltration air volume. The changes of infiltration air volume was analyzed, and the corresponding measures to reduce the infiltration air were studied. The results showed that using air curtains with the barrier efficiency of 62.6% and closing the opening windows, the static wind and v=3 m/s of northeast wind conditions, the amount of infiltration air can be reduced by 78% and 79% separately in Wuhan area.