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Alauddin, Mian M; Shahinian, Atranik; Gordon, Erlinda M; Conti, Peter S
Molecular imaging 3, Številka: 2Journal Article
2'-Deoxy-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU), 9-(4-fluoro-3-hydroxy-methyl-butyl)guanine (FHBG) and 9-(3-fluoro-1-hydroxy-2-propoxy)methyl-guanine (FHPG) have been evaluated in a human breast cancer model as potential radiotracers for PET imaging of HSV1-tk gene expression. In vitro accumulation of 14CFMAU, 18FFHBG, and 18FFHPG in HSV1-tk-expressing cells was 14- to 16-fold (p <.001), 9- to 13-fold (p <.001), and 2- to 3-fold (p <.05) higher than tk-negative control cells, respectively, between 30 and 240 min. Accumulation of FMAU and FHBG in vector-transduced cells was 10- to 14-fold and 6- to 10-fold higher than wild-type cells, respectively. At 2 hr, uptake of (14)CFMAU in tkpositive cells was 6.3-fold and 60-fold higher than 18FFHBG and 18FFHPG, respectively. In vivo, tumor uptake of 14CFMAU in HSV1-tk-expressing cells was 3.7-fold and 5.5-fold (p <.001) higher than tk-negative control cells at 1 and 2 hr, respectively. Tumor uptake of 18FFHBG was 4.2-fold and 12.6-fold higher (p <.001) than tk-negative cells at the same time points. Incorporation of 14CFMAU in tk-positive tumor was 18-fold and 24-fold higher (p <.001) than 18FFHBG at 1 and 2 hr, respectively. Micro-PET images support the biodistribution results and indicate that both 18FFMAU and 18FFHBG are useful for imaging HSV1-tk expression in breast cancer. Although FMAU demonstrates higher total incorporation (%dose/g) in tumor tissue compared with the other tracers, FHBG is superior in terms of specific accumulation in transfected cells at later time points.
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