This paper presents a scenario-based study that investigates the interaction between sea-level rise and land subsidence on the storm tides induced fluvial flooding in the Huangpu river floodplain. Two projections of relative sea level rise (RSLR) were presented (2030 and 2050). Water level projections at the gauging stations for different return periods were generated using a simplified algebraic summation of the eustatic sea-level rise, land subsidence and storm tide level. Frequency analysis with relative sea level rise taken into account shows that land subsidence contributes to the majority of the RSLR (between 60 % and 70 %). Furthermore, a 1D/2D coupled flood inundation model (FloodMap) was used to predict the river flow and flood inundation, after calibration using the August 1997 flood event. Numerical simulation with projected RSLR suggests that, the combined impact of eustatic sea-level rise and land subsidence would be a significantly reduced flood return period for a given water level, thus effective degradation of the current flood defences. In the absence of adaptation measures, storm flooding will cause up to 40 % more inundation, particularly in the upstream of the river.