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Zhang, Fan; Zhao, Miao; Braun, Doug R; Ericksen, Spencer S; Piotrowski, Jeff S; Nelson, Justin; Peng, Jian; Ananiev, Gene E; Chanana, Shaurya; Barns, Kenneth; Fossen, Jen; Sanchez, Hiram; Chevrette, Marc G; Guzei, Ilia A; Zhao, Changgui; Guo, Le; Tang, Weiping; Currie, Cameron R; Rajski, Scott R; Audhya, Anjon; Andes, David R; Bugni, Tim S
Science, 11/2020, Letnik: 370, Številka: 6519Journal Article
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug-resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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