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Handke, Analena; Axelsson, John; Benson, Sven; Boy, Karoline; Weskamp, Vera; Hasenberg, Till; Remy, Miriam; Hebebrand, Johannes; Föcker, Manuel; Brinkhoff, Alexandra; Unteroberdörster, Meike; Engler, Harald; Schedlowski, Manfred; Lasselin, Julie
Brain, behavior, & immunity. Health, 10/2020, Letnik: 8Journal Article
Data from clinical and cross-sectional studies suggest that inflammation contributes to psychomotor slowing and attentional deficits found in depressive disorder. However, experimental evidence is still lacking. The aim of this study was to clarify the effect of inflammation on psychomotor slowing using an experimental and acute model of inflammation, in which twenty-two healthy volunteers received an intravenous injection of lipopolysaccharide (LPS, dose: 0.8 ng/kg body weight) and of placebo, in a randomized order following a double-blind within-subject crossover design. A reaction time test and a go/no-go test were conducted 3 h after the LPS/placebo injection and interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations were assessed. No effect of experimental inflammation on reaction times or errors for either test was found. However, inflammation was related to worse self-rated performance and lower effort put in the tasks. Exploratory analyses indicated that reaction time fluctuated more over time during acute inflammation. These data indicate that acute inflammation has only modest effects on psychomotor speed and attention in healthy subjects objectively, but alters the subjective evaluation of test performance. Increased variability in reaction time might be the first objective sign of altered psychomotor ability and would merit further investigation. •The effect of experimental inflammation on psychomotor slowing was assessed.•Acute inflammation does not affect psychomotor speed in two reaction time tasks.•Inflammation altered the subjective evaluation of test performance.•In exploratory analyses, the variability of reaction time over time was affected.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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