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Qu, Liang; Yi, Zongyi; Shen, Yong; Lin, Liangru; Chen, Feng; Xu, Yiyuan; Wu, Zeguang; Tang, Huixian; Zhang, Xiaoxue; Tian, Feng; Wang, Chunhui; Xiao, Xia; Dong, Xiaojing; Guo, Li; Lu, Shuaiyao; Yang, Chengyun; Tang, Cong; Yang, Yun; Yu, Wenhai; Wang, Junbin; Zhou, Yanan; Huang, Qing; Yisimayi, Ayijiang; Liu, Shuo; Huang, Weijin; Cao, Yunlong; Wang, Youchun; Zhou, Zhuo; Peng, Xiaozhong; Wang, Jianwei; Xie, Xiaoliang Sunney; Wei, Wensheng
Cell, 05/2022, Letnik: 185, Številka: 10Journal Article
As the emerging variants of SARS-CoV-2 continue to drive the worldwide pandemic, there is a constant demand for vaccines that offer more effective and broad-spectrum protection. Here, we report a circular RNA (circRNA) vaccine that elicited potent neutralizing antibodies and T cell responses by expressing the trimeric RBD of the spike protein, providing robust protection against SARS-CoV-2 in both mice and rhesus macaques. Notably, the circRNA vaccine enabled higher and more durable antigen production than the 1mΨ-modified mRNA vaccine and elicited a higher proportion of neutralizing antibodies and distinct Th1-skewed immune responses. Importantly, we found that the circRNARBD-Omicron vaccine induced effective neutralizing antibodies against the Omicron but not the Delta variant. In contrast, the circRNARBD-Delta vaccine protected against both Delta and Omicron or functioned as a booster after two doses of either native- or Delta-specific vaccination, making it a favorable choice against the current variants of concern (VOCs) of SARS-CoV-2. Display omitted •Highly stable circRNA vaccines induce potent humoral and cellular immune responses•CircRNA vaccines elicit a high proportion of neutralizing antibodies•CircRNA vaccines enable effective protection against SARS-CoV-2 in mice and monkeys•CircRNARBD-Delta vaccine provides broad-spectrum protection against SARS-CoV-2 VOCs A circular RNA (circRNA) vaccine that encodes the trimeric RBD antigens of SARS-CoV-2 spike provides protection and memory boosting against SARS-CoV-2 variants of concern, in mice and rhesus macaques.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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