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Liu, S. John; Horlbeck, Max A.; Cho, Seung Woo; Birk, Harjus S.; Malatesta, Martina; He, Daniel; Attenello, Frank J.; Villalta, Jacqueline E.; Cho, Min Y.; Chen, Yuwen; Mandegar, Mohammad A.; Olvera, Michael P.; Gilbert, Luke A.; Conklin, Bruce R.; Chang, Howard Y.; Weissman, Jonathan S.; Lim, Daniel A.
Science, 01/2017, Letnik: 355, Številka: 6320Journal Article
The human genome produces thousands of long noncoding RNAs (lncRNAs)-transcripts >200 nucleotides long that do not encode proteins. Although critical roles in normal biology and disease have been revealed for a subset of lncRNAs, the function of the vast majority remains untested. We developed a CRISPR interference (CRISPRi) platform targeting 16,401 lncRNA loci in seven diverse cell lines, including six transformed cell lines and human induced pluripotent stem cells (iPSCs). Large-scale screening identified 499 lncRNA loci required for robust cellular growth, of which 89% showed growth-modifying function exclusively in one cell type. We further found that lncRNA knockdown can perturb complex transcriptional networks in a cell type-specific manner. These data underscore the functional importance and cell type specificity of many lncRNAs.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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