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Ding, Jiarui; Garber, John J; Uchida, Amiko; Lefkovith, Ariel; Carter, Grace T; Vimalathas, Praveen; Canha, Lauren; Dougan, Michael; Staller, Kyle; Yarze, Joseph; Delorey, Toni M; Rozenblatt-Rosen, Orit; Ashenberg, Orr; Graham, Daniel B; Deguine, Jacques; Regev, Aviv; Xavier, Ramnik J
Nature communications, 04/2024, Letnik: 15, Številka: 1Journal Article
Coordinated cell interactions within the esophagus maintain homeostasis, and disruption can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly understood pathogenesis. We profile 421,312 individual cells from the esophageal mucosa of 7 healthy and 15 EoE participants, revealing 60 cell subsets and functional alterations in cell states, compositions, and interactions that highlight previously unclear features of EoE. Active disease displays enrichment of ALOX15 macrophages, PRDM16 dendritic cells expressing the EoE risk gene ATP10A, and cycling mast cells, with concomitant reduction of T 17 cells. Ligand-receptor expression uncovers eosinophil recruitment programs, increased fibroblast interactions in disease, and IL-9 IL-4 IL-13 T 2 and endothelial cells as potential mast cell interactors. Resolution of inflammation-associated signatures includes mast and CD4 T cell contraction and cell type-specific downregulation of eosinophil chemoattractant, growth, and survival factors. These cellular alterations in EoE and remission advance our understanding of eosinophilic inflammation and opportunities for therapeutic intervention.
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