E-viri
Recenzirano
Odprti dostop
-
Constantinides, Michael G; Link, Verena M; Tamoutounour, Samira; Wong, Andrea C; Perez-Chaparro, P Juliana; Han, Seong-Ji; Chen, Y Erin; Li, Kelin; Farhat, Sepideh; Weckel, Antonin; Krishnamurthy, Siddharth R; Vujkovic-Cvijin, Ivan; Linehan, Jonathan L; Bouladoux, Nicolas; Merrill, E Dean; Roy, Sobhan; Cua, Daniel J; Adams, Erin J; Bhandoola, Avinash; Scharschmidt, Tiffany C; Aubé, Jeffrey; Fischbach, Michael A; Belkaid, Yasmine
Science (American Association for the Advancement of Science), 10/2019, Letnik: 366, Številka: 6464Journal Article
How early-life colonization and subsequent exposure to the microbiota affect long-term tissue immunity remains poorly understood. Here, we show that the development of mucosal-associated invariant T (MAIT) cells relies on a specific temporal window, after which MAIT cell development is permanently impaired. This imprinting depends on early-life exposure to defined microbes that synthesize riboflavin-derived antigens. In adults, cutaneous MAIT cells are a dominant population of interleukin-17A (IL-17A)-producing lymphocytes, which display a distinct transcriptional signature and can subsequently respond to skin commensals in an IL-1-, IL-18-, and antigen-dependent manner. Consequently, local activation of cutaneous MAIT cells promotes wound healing. Together, our work uncovers a privileged interaction between defined members of the microbiota and MAIT cells, which sequentially controls both tissue-imprinting and subsequent responses to injury.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.