E-viri
Recenzirano
Odprti dostop
-
Carrot-Zhang, Jian; Chambwe, Nyasha; Damrauer, Jeffrey S.; Knijnenburg, Theo A.; Robertson, A. Gordon; Yau, Christina; Zhou, Wanding; Berger, Ashton C.; Huang, Kuan-lin; Newberg, Justin Y.; Mashl, R. Jay; Romanel, Alessandro; Sayaman, Rosalyn W.; Demichelis, Francesca; Felau, Ina; Frampton, Garrett M.; Han, Seunghun; Hoadley, Katherine A.; Kemal, Anab; Laird, Peter W.; Lazar, Alexander J.; Le, Xiuning; Oak, Ninad; Shen, Hui; Wong, Christopher K.; Zenklusen, Jean C.; Ziv, Elad; Aguet, Francois; Ding, Li; Demchok, John A.; Mensah, Michael K.A.; Caesar-Johnson, Samantha; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Alfoldi, Jessica; Karczewski, Konrad J.; MacArthur, Daniel G.; Meyerson, Matthew; Benz, Christopher; Stuart, Joshua M.; Cherniack, Andrew D.; Beroukhim, Rameen
Cancer cell, 05/2020, Letnik: 37, Številka: 5Journal Article
We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas. We demonstrated that cancer subtypes and ancestry-related technical artifacts are important confounders that have been insufficiently accounted for. Once accounted for, ancestry-associated differences spanned all molecular features and hundreds of genes. Biologically significant differences were usually tissue specific but not specific to cancer. However, admixture and pathway analyses suggested some of these differences are causally related to cancer. Specific findings included increased FBXW7 mutations in patients of African origin, decreased VHL and PBRM1 mutations in renal cancer patients of African origin, and decreased immune activity in bladder cancer patients of East Asian origin. Display omitted •This large analysis identified ancestry correlates in cancer•Ancestry-associated artifacts and confounders were identified•Ancestry effects are profoundly tissue specific•Rates of FBXW7, VHL, and PBRM1 mutations and immune activity vary by ancestry Analyzing mutation rates, gene and miRNA expression, and DNA methylation across tumor types, Carrot-Zhang et al. separate confounders and identify ancestry-related effects that potentially explain cancer etiology and treatment.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.