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Li, Zhi-Hao; Wang, Xiao-Meng; Liao, Dan-Qing; Zhang, Qian; Chen, Zi-Ting; Qiu, Cheng-Shen; Tang, Xu-Lian; Li, Hong-Min; Du, Li-Ying; Zhang, Pei-Dong; Shen, Dong; Zhang, Xi-Ru; Gao, Jian; Zhong, Wen-Fang; Chen, Pei-Liang; Huang, Qing-Mei; Song, Wei-Qi; Liu, Dan; Li, Chuan; Chen, Huan; Mao, Chen
Ecotoxicology and environmental safety, 04/2024, Letnik: 274Journal Article
Ambient air pollution is a major global health concern. Yet, no study has thoroughly assessed its link to respiratory mortality. Our research evaluated the combined and individual effects of air pollutants on respiratory mortality risks based on the UK Biobank. A total of 366,478 participants were studied. A Cox proportional hazards model was used to estimate the respiratory mortality risk from combined long-term exposure to five pollutants, summarized as a weighted air pollution score. During a median of 13.6 years of follow-up, 6113 deaths due to respiratory diseases were recorded. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of respiratory diseases were 2.64 (2.05–3.39), 1.62 (1.23–2.12), 2.06 (1.73–2.45), 1.20 (1.16–1.25), and 1.07 (1.05–1.08) per 10 μg/m3 increase in PM2.5, PM2.5–10, PM10, NO2, and NOx, respectively. The air pollution score showed a dose-response association with an elevated respiratory mortality risk. The highest versus lowest quartile air pollution score was linked to a 44% increase in respiratory mortality risk (HR 1.44, 95% CI: 1.33–1.57), with consistent findings in subgroup and sensitivity analyses. Long-term individual and joint air-pollutant exposure showed a dose-response association with an increased respiratory mortality risk, highlighting the importance of a comprehensive air-pollutant assessment to protect public health. Display omitted •Air pollution is a risk factor for respiratory mortality.•Long-term exposure to air pollution increased respiratory mortality risk.•The AP score showed a dose-response association with respiratory mortality risk.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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