A simple and sensitive spectrophotometric method has been developed for the assay of lercanidipine hydrochloride (LER) in bulk and in formulations. The method is based on the formation of coloured species between the drug and 1,2-naphthaquinone-4-sulphonic acid sodium salt (NQS) by means of nucleophilic substitution reaction. Absorbance was measured at λmax = 460 nm. The method was analyzed statistically. The system obeyed the Beer's law in the range 20-100 μg mL-1. Molar absorptivity value was found to be 4.79 × 103 L mol-1 cm-1. Limits of detection and quantification were found to be as low as 0.04 and 0.13 μg mL-1. Precision (RSD, 0.4 %) and accuracy (recovery 99.2 ± 0.6 to 101.1 ± 0.8 %) of the developed method were evaluated. Razvijena je osjetljiva spektrofotometrijska metoda za određivanje lerkanidipin hidroklorida (LER) u čistoj tvari i ljekovitim oblicima. Metoda se temelji na stvaranju obojenih produkata između ljekovite tvari i natrijeve soli 1,2-naftakinon-4-sulfonske kiseline (NQS) reakcijom nukleofilne supstitucije. Apsorbancija je mjerena pri λmax = 460 nm. Metoda je obrađena statistički. Sistem je slijedio Beerov zakon u koncentracijskom području 20-100 mg mL-1. Molarni apsorpcijski koeficijent iznosio je 4,79 × 103 L mol-1 cm-1, granice detekcije i kvantifikacije 0,04, odnosno 0,13 mg mL-1. Nepreciznost i ispravnost metode iznosile su 0,4 %, odnosno 99,2 ± 0,6 do 101,1 ± 0,8 %.