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Streitberger, Kaspar-Josche; Fehlner, Andreas; Pache, Florence; Lacheta, Anna; Papazoglou, Sebastian; Bellmann-Strobl, Judith; Ruprecht, Klemens; Brandt, Alexander; Braun, Jürgen; Sack, Ingolf; Paul, Friedemann; Wuerfel, Jens
European radiology, 05/2017, Letnik: 27, Številka: 5Journal Article
Objectives Application of multifrequency magnetic resonance elastography (MMRE) of the brain parenchyma in patients with neuromyelitis optica spectrum disorder (NMOSD) compared to age matched healthy controls (HC). Methods 15 NMOSD patients and 17 age- and gender-matched HC were examined using MMRE. Two three-dimensional viscoelastic parameter maps, the magnitude |G*| and phase angle φ of the complex shear modulus were reconstructed by simultaneous inversion of full wave-field data in 1.9-mm isotropic resolution at 7 harmonic drive frequencies from 30 to 60 Hz. Results In NMOSD patients, a significant reduction of |G*| was observed within the white matter fraction ( p = 0.017), predominantly within the thalamic regions ( p = 0.003), compared to HC. These parameters exceeded the reduction in brain volume measured in patients versus HC ( p = 0.02 whole-brain volume reduction). Volumetric differences in white matter fraction and the thalami were not detectable between patients and HC. However, phase angle φ was decreased in patients within the white matter ( p = 0.03) and both thalamic regions ( p = 0.044). Conclusions MMRE reveals global tissue degeneration with accelerated softening of the brain parenchyma in patients with NMOSD. The predominant reduction of stiffness is found within the thalamic region and related white matter tracts, presumably reflecting Wallerian degeneration. Key Points • Magnetic resonance elastography reveals diffuse cerebral tissue changes in patients with NMOSD. • Premature tissue softening in NMOSD patients indicates tissue degeneration. • Hypothesis of a widespread cerebral neurodegeneration in form of diffuse tissue alteration.
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