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  • Generation of two SPAST kno...
    Generation of two SPAST knockout human induced pluripotent stem cell lines to create a model for Hereditary Spastic Paraplegia type 4
    Korneck, M.; Wiora, L.; Schöls, L.; Hauser, S.

    Stem cell research, April 2022, 2022-04-00, 20220401, 2022-04-01, Letnik: 60
    Journal Article

    Spastin is a an ATPase that severs microtubules therby regulating amount and mobility of these structures. Mutations in the SPAST gene (SPG4) are the most common form of Hereditary Spastic Paraplegia (HSP). Here, we report the generation of a homozygous and a heterozygous SPAST knockout induced pluripotent stem cell (iPSC) line from a healthy control iPSC line using CRISPR/Cas9 technology.

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