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Kokovay, Erzsebet; Goderie, Susan; Wang, Yue; Lotz, Steve; Lin, Gang; Sun, Yu; Roysam, Badrinath; Shen, Qin; Temple, Sally
Cell stem cell, 08/2010, Letnik: 7, Številka: 2Journal Article
Neural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are associated with ependymal and vasculature niches, which regulate stem cell self-renewal and differentiation. Activated Type B stem cells and their progeny, the transit-amplifying type C cells, which express EGFR, are most highly associated with vascular cells, indicating that this niche supports lineage progression. Here, we show that proliferative SVZ progenitor cells home to endothelial cells in a stromal-derived factor 1 (SDF1)- and CXC chemokine receptor 4 (CXCR4)-dependent manner. We show that SDF1 strongly upregulates EGFR and α6 integrin in activated type B and type C cells, enhancing their activated state and their ability to bind laminin in the vascular niche. SDF1 increases the motility of type A neuroblasts, which migrate from the SVZ toward the olfactory bulb. Thus, differential responses to SDF1 can regulate progenitor cell occupancy of and exit from the adult SVZ vascular niche. ► Neural stem cells home to the vascular niche in an SDF1/CXCR4-dependent manner ► Different progenitor populations show different responses to SDF1 ► SDF1 upregulates integrin α6 and EGFR in distinct progenitor populations
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