Many of the children referred to the emergency complain of head trauma. Children usually require sedition to reduce their failure and fear because of high activity and fear of performing computed tomography (CT). Dexmedetomidine and Midazolam belong to short-acting drugs for this purpose. This study aimed to compare the effect of the above mentioned drugs on sedition in children. Children referred to the emergency department were randomly divided into two groups. Group A was sedated with 0.05 mg/kg IV Midazolam and group B with 2μg/kg IV Dexmedetomidine over 10 minutes (loading dose), and then repeat boluses 2μg/kg IV over 10 minutes. Measurements included induction time, recovery time, efficacy, side effects, complications, and failure with each drug and vital signs and RAMSY scale. SPSS V.20 was used for data analysis. p<0.05 was considered statistically significant. Totally, 100 patients participated in the current study (44 girls and 56 boys). The mean and standard deviation of age was 5.3 ± 2.5 years. During the study, just 5 patients (10%) from group A did not have appropriate sedition following the injection of first dose of Midazolam and received the second dose. However, in B group patients no such case was reported. No significant difference was observed among blood pressure, heart rate, respiration and RAMSY Scale among the groups. No significant difference was seen between efficacy of Midazolam and Dexmedetomidine in pediatric sedation. More research should be done for generalization of our findings . Veliki broj dece koja se upućuju na Odeljenje urgentne medicine javlja se zbog povreda glave. Najčešće se deci daju sedativi kako bi se umirila i savladala strah zbog CT snimanja. Deksmedetomidin i Midazolam pripadaju grupi brzo-delujućih lekova koji se primenjuju u ove svrhe. Cilj ove studije bio je upoređivanje efekata pomenutih lekova na umirenje dece. Deca koja su upućena na Odeljenje urgentne medicine nasumice su podeljena u dve grupe. Deci iz grupe A je dat Midazolam IV u dozi od 0,05 mg/kg, a grupi B Deksmedetomidin u dozi od 2 μg/kg u trajanju od 10 minuta (početna doza), a potom i ponovljena doza od 2 μg/kg u trajanju od 10 minuta. Merenja su uključila vreme indukcije, vreme oporavka, efikasnost, propratne efekte, komplikacije, neefikasnost svakog leka pojedinačno, vitalne znake i Ramsy skalu. Za analizu podataka korišćena je SPSS verzija 20. Kao statistički značajna vrednost uzeta je p<0,05. U studiji je učestvovalo ukupno 100 bolesnika (44 devojčice i 56 dečaka). Srednja i standardna devijacija godina starosti iznosila je 5,3±2,5 godina. U toku studije, samo 5 (10%) bolesnika iz grupe A nije bilo dovoljno umireno nakon prve doze Midazolama, te im je data druga doza. Nije uočena statistički značajna razlika među grupama u vrednostima krvnog pritiska, srčanog rada, respiracije i RAMSY skale. Nije pronađena statistički značajna razlika u efikasnosti Midazolama i Deksmedetomidina za umirenje pedijatrijske populacije. Neophodno je sprovesti nova istraživanja za izvođenje opštih zaključaka o dobijenim rezultatima.