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López-Nájera, Diego; Rubio-Zaragoza, Mónica; Sopena-Juncosa, Joaquín J.; Alentorn-Geli, Eduard; Cugat-Bertomeu, Ramón; Fernández-Sarmiento, J. Andrés; Domínguez-Pérez, Juan M.; García-Balletbó, Montserrat; Primo-Capella, Víctor J.; Carrillo-Poveda, José M.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 12/2016, Letnik: 24, Številka: 12Journal Article
Purpose To assess the biomechanical effects of intra-tendinous injections of PRGF on the healing Achilles tendon after repair in a sheep model. Methods Thirty sheep were randomly assigned into one of the six groups depending on the type of treatment received (PRGF or placebo) and survival time (2, 4 and 8 weeks). The Achilles tendon injury was repaired by suturing the tendinous edges employing a three-loop pulley pattern. A trans-articular external fixation system was then used for immobilization. The PRGF or placebo was administered on a weekly basis completing a maximum of three infiltrations. The force, section and tension values were compared between the operated and healthy Achilles tendons across all groups. Results The PRGF-treated tendons had higher force at 8 weeks compared with the placebo group ( p = 0.007). Between 2 and 4 weeks, a significant increase in force in both the PRGF-treated tendon ( p = 0.0027) and placebo group ( p = 0.0095) occurred. No significant differences were found for section ratio between PRGF-treated tendons and the placebo group for any of the time periods evaluated. At 2 weeks, PRGF-treated tendons had higher tension ratio compared with placebo group tendons ( p = 0.0143). Both PRGF and placebo treatments significantly improved the force ( p < 0.001 and p = 0.0095, respectively) and tension ( p = 0.009 and p = 0.0039, respectively) ratios at 8 weeks compared with 2 weeks. Conclusion The application of PRGF increases Achilles tendon repair strength at 8 weeks compared with the use of placebo. The use of PRGF does not modify section and tension ratios compared with placebo at 8 weeks. The tension ratio progressively increases between 2 and 8 weeks compared with the placebo.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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