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Gandhi, Chandrashekhar R.
Journal of hepatology, 11/2017, Letnik: 67, Številka: 5Journal Article
Regardless of etiology, hepatic stellate cells (HSCs) are the major contributors to fibrosis/cirrhosis. Bone marrow-derived fibrocytes, epithelial-to-mesenchymal transition and portal fibroblasts (Pfb) are other sources, but their contribution is much lower. Pfb are important in the early stages of the disease, but HSCs are predominantly responsible for the progression of the disease, even for biliary fibrosis. Physiologically quiescent, HSCs become rapidly activated and transdifferentiate into proliferative, contractile and fibrogenic myofibroblast-like cells during liver injury.
