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Hegab, Ahmed E.; Ozaki, Mari; Meligy, Fatma Y.; Kagawa, Shizuko; Ishii, Makoto; Betsuyaku, Tomoko
Stem cell research, 12/2018, Letnik: 33Journal Article
High fat diet (HFD) decreases the lifespan of mice, and is a risk factor for several human diseases. Here, we investigated the effects of a HFD on lung epithelial and stem cells and its interaction with aging. Young and old mice were fed with either a standard diet (SD) or a HFD then their trachea and lung were examined for histological changes, inflammation, and mitochondrial function. Their stem cell function was examined using the in vitro organoid/colony forming efficiency (CFE) assay. Aging reduced the number of tracheal basal and alveolar type-2 (AT2) cells. HFD significantly increased the number of AT2 cells. Aging also caused a significant increase in lung inflammation, and HFD caused a similar increase, in young mice. Aging reduced mitochondrial mass and function, and increased reactive oxygen species. In young mice, HFD caused mitochondrial changes similar to the aging-induced changes. Organoid culture of tracheal and lung epithelial cells collected from both young and old HFD-fed mice showed higher CFE compared to SD-fed mice. Switching the HFD to low calorie/fat diet (LCD) efficiently reversed several of the HFD-induced effects. Thus, HFD induces several histological, inflammatory, and functional changes in the lung, and exacerbates the aging-induced lung inflammation and mitochondrial deterioration. LCD can reverse many of the HFD-induced effects. Display omitted •High fat diet (HFD) caused an increase in the number of alveolar type-2 cells.•Both aging and HFD caused an increase in inflammatory cell infiltration of the lung.•Both aging and HFD impaired various aspects of mitochondrial function.•HFD promoted in vitro colony formation by lung stem cells, while aging inhibited it.•Switching the diet to a low FD reversed several of the HFD-induced effects.
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