E-viri
Recenzirano
Odprti dostop
-
Chau, Nicole G.; Hurwitz, Shelley; Mitchell, Chelsey M.; Aserlind, Alexandra; Grunfeld, Noam; Kaplan, Leah; Hsi, Peter; Bauer, Daniel E.; Lathan, Christopher S.; Rodriguez‐Galindo, Carlos; Tishler, Roy B.; Haddad, Robert I.; Sallan, Stephen E.; Bradner, James E.; French, Christopher A.
Cancer, December 1, 2016, Letnik: 122, Številka: 23Journal Article
BACKGROUND NUT midline carcinoma is a rare and aggressive genetically characterized subtype of squamous cell carcinoma frequently arising from the head and neck. The characteristics and optimal management of head and neck NUT midline carcinoma (HNNMC) are unclear. METHODS A retrospective review of all known cases of HNNMC in the International NUT Midline Carcinoma Registry as of December 31, 2014, was performed. Forty‐eight consecutive patients were treated from 1993 to 2014, and clinicopathologic variables and outcomes for 40 patients were available for analyses; they composed the largest HNNMC cohort studied to date. Overall survival (OS) and progression‐free survival (PFS) according to patient characteristics and treatment were analyzed. RESULTS This study identified a 5‐fold increase in the diagnosis of HNNMC from 2011 to 2014. The median age was 21.9 years (range, 0.1‐81.7 years); the male and female proportions were 40% and 60%, respectively; and 86% had bromodomain containing 4–nuclear protein in testis (BRD4‐NUT) fusion. The initial treatment was initial surgery with or without adjuvant chemoradiation or adjuvant radiation (56%), initial radiation with or without chemotherapy (15%), or initial chemotherapy with or without surgery or radiation (28%). The median PFS was 6.6 months (range, 4.7‐8.4 months). The median OS was 9.7 months (range, 6.6‐15.6 months). The 2‐year PFS rate was 26% (95% confidence interval CI, 13%‐40%). The 2‐year OS rate was 30% (95% CI, 16%‐46%). Initial surgery with or without postoperative chemoradiation or radiation (P = .04) and complete resection with negative margins (P = .01) were significant predictors of improved OS even after adjustments for age, tumor size, and neck lymphadenopathy. Initial radiation or chemotherapy and the NUT translocation type were not associated with outcomes. CONCLUSIONS HNNMC portends a poor prognosis. Aggressive initial surgical resection with or without postoperative chemoradiation or radiation is associated with significantly enhanced survival. Chemotherapy or radiation alone is often inadequate. Cancer 2016;122:3632‐40. © 2016 American Cancer Society. NUT midline carcinoma of the head and neck is an extremely rare and aggressive subtype of squamous cell carcinoma. In this analysis of the largest cohort of head and neck NUT midline carcinomas studied to date, aggressive initial surgical resection with or without postoperative radiation or chemoradiation is associated with improved outcomes.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.