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Zhou, Y.T; Shimabukuro, M; Wang, M.Y; Lee, Y; Higa, M; Milburn, J.L; Newgard, C.B; Unger, R.H
Proceedings of the National Academy of Sciences - PNAS, (21 Jul 1998), 19980721, 1998-07-21, 1998-Jul-21, Letnik: 95, Številka: 15Journal Article
Expression of peroxisome proliferator- activated receptor alpha (PPAR alpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPAR alpha/retinoid x receptor ligands, and FA all up-regulate PPAR alpha and enzymes of FA oxidation and stimulate 3H-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPAR alpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells
