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Dash, Suravi Sasmita; Arunachal, Gautham; Nimonkar, Madhura Milind; Vengalil, Seena; Nashi, Saraswati; Chetan, Ghati K.; Boddu, Vijay Kumar; Nalini, Atchayaram; Markandeya, Yogananda S.
Stem cell research, April 2024, 2024-Apr, 2024-04-00, 20240401, 2024-04-01, Letnik: 76Journal Article
In this study, we have established human induced pluripotent stem cell (hiPSC) line, NIMHi010-A of a 42-year-old healthy donor. The iPSC line was generated from human dermal fibroblasts using Sendai viruses carrying reprogramming factors c-MYC, SOX2, KLF4, and OCT4 under a feeder-free culture system. The generated hiPSC line expressed typical pluripotency markers, displayed a normal karyotype, and demonstrated the potential to differentiate into the three germ layers. This hiPSC line will serve as a healthy control model for physiological processes and drug screening of Asian origin from Indian population.
