Eicosanoids are a class of bioactive lipids produced from the oxygenation of polyunsaturated fatty acid precursors, including the primary omega-6 fatty acids (linoleic acid LA and arachidonic acid AA) and omega-3 fatty acids (docosahexaenoic acid DHA and eicosapentaenoic acid EPA) 12. Namely, 1 participant previously categorized as AGA was recategorized as SGA, and 2 participants previously categorized as LGA were recategorized as AGA. ...our final distribution of outcome groups was 31 SGA cases, 31 AGA controls, and 28 LGA cases. Eicosanoid quantification A panel of eicosanoids and fatty acids was measured in plasma samples by the Mass Spectrometry Research and Support Group at the National Institute of Environmental Health Sciences (Research Triangle, NC, US) in 2018. The eicosanoid pathway is defined by a fatty acid precursor—linoleic acid (LA), arachidonic acid (AA), docosahexaenoic acid (DHA), or eicosapentaenoic acid (EPA)—that is metabolized by an enzyme—cytochrome P450 (CYP), lipoxygenase (LOX), or cyclooxygenase (COX).