Subjective cognitive complaints (SCCs) are considered a risk factor for objective cognitive decline and conversion to dementia. The aim of this study was to determine whether self-reported or informant-reported SCCs best predict progression to mild cognitive impairment (MCI) and/or dementia. We reviewed prospective longitudinal studies of Cognitively Unimpaired (CU) older adults with self-reported and informant-reported SCCs at baseline, assessed by questions or questionnaires that considered the transition to MCI and/or dementia. A random-effects meta-analysis was performed to obtain pooled estimates and 95% CIs. Both self-reported and informant-reported SCCs are associated with an elevated risk of transition from CU to MCI and/or dementia. The association appears stronger and more robust for informant-reported data 1.38, with a 95% CI of 1.16 –1.64, p < 0.001 than for self-reported data 1.27 (95% CI 1.06 – 1.534, p = 0.011. Our results suggest that corroborated information from one informant could provide important details for distinguishing between normal aging and clinical states. •SCCs are considered a risk factor for objective cognitive decline.•Both, self-reported and informant-reported SCCs, predict progression to MCI/dementia.•The risk association was significant more stronger for informant-reported.•The confirmation by a family member is required at pre-symptomatic stages.