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Recenzirano
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Boldrini, Vinícius Oliveira; Brito, Mariana Rabelo; Quintiliano, Raphael Patrício Silva; Scárdua Silva, Lucas; Yasuda, Clarissa Lin; Cendes, Fernando; Farias, Alessandro Santos; Damasceno, Alfredo
Frontiers in neurology, 08/2023, Letnik: 14Journal Article
Background The expression of serine protease granzyme-B (GzmB) by circulating CD8 + T lymphocytes has been recently suggested as a biomarker for poor immunotherapy response and severe disability in patients with Neuromyelitis Optica spectrum disorders (NMOSD). In parallel, venous thromboembolism (VTE) has been reported mainly in NMOSD patients exhibiting transverse myelitis. Case presentation Here, we describe an Aquaporin-4 positive (AQP4-positive) NMOSD patient who showed short myelitis (SM) and experienced a fatal pulmonary thromboembolism/lower extremity deep vein thrombosis during anti-CD20 treatment. Flow cytometry analyses from the peripheral blood revealed an enhanced cytotoxic behavior through circulating CD8 + GzmB + T, CD4 + GzmB + T lymphocytes, and residual CD19 + GzmB + B cells. Conclusions Fatal VTE may be a rare outcome, particularly in patients exhibiting SM, and may share poorly understood immunological mechanisms with AQP4-positive NMOSD severity.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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