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Rossi-Ashton, James A; Clarke, Aimee K; Taylor, Richard J. K; Unsworth, William P
Organic letters, 02/2020, Letnik: 22, Številka: 3Journal Article
The polycyclic core of the akuammiline alkaloids can be synthesized from simple tryptamine and tryptophol derivatives via a Ag(I)-catalyzed enantioselective dearomative cyclization cascade sequence. The complex tetracyclic scaffolds are prepared via a rapid, versatile, three-step modular synthesis from simple commercially available indole derivatives in high yields and enantiomeric excess (up to 99% yield and >99% ee).
