E-viri
Recenzirano
Odprti dostop
-
Gaudio, Eugenio; Tarantelli, Chiara; Spriano, Filippo; Guidetti, Francesca; Sartori, Giulio; Bordone, Roberta; Arribas, Alberto J; Cascione, Luciano; Bigioni, Mario; Merlino, Giuseppe; Fiascarelli, Alessio; Bressan, Alessandro; Mensah, Afua Adjeiwaa; Golino, Gaetanina; Lucchini, Renzo; Bernasconi, Elena; Rossi, Davide; Zucca, Emanuele; Stussi, Georg; Stathis, Anastasios; Boyd, Robert S; Dusek, Rachel L; Bisht, Arnima; Attanasio, Nickolas; Rohlff, Christian; Pellacani, Andrea; Binaschi, Monica; Bertoni, Francesco
Haematologica (Roma), 11/2020, Letnik: 105, Številka: 11Journal Article
Antibody drug conjugates represent an important class of anti-cancer drugs in both solid tumors and hematological cancers. Here, we report preclinical data on the anti-tumor activity of the first-in-class antibody drug conjugate MEN1309/OBT076 targeting CD205. The study included preclinical in vitro activity screening on a large panel of cell lines, both as single agent and in combination and validation experiments on in vivo models. CD205 was first shown frequently expressed in lymphomas, leukemias and multiple myeloma by immunohistochemistry on tissue microarrays. Anti-tumor activity of MEN1309/OBT076 as single agent was then shown across 42 B-cell lymphoma cell lines with a median IC50 of 200 pM and induction of apoptosis in 25/42 (59.5%) of the cases. The activity appeared highly correlated with its target expression. After in vivo validation as the single agent, the antibody drug conjugate synergized with the BCL2 inhibitor venetoclax, and the anti-CD20 monoclonal antibody rituximab. The first-in-class antibody drug targeting CD205, MEN1309/OBT076, demonstrated strong pre-clinical anti-tumor activity in lymphoma, warranting further investigations as a single agent and in combination.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.