This paper takes Deppon Express Company as an example to study the optimization of the layout of the store warehouse under the standardized operation mode. First of all, it Analyzes warehouse layout present situation of the express company, and gets the problems of the warehouse layout of the company, for example, the layout of the lack of scientific, as well as part of the operational areas of position arrangement is not reasonable and unreasonable action path which leads to the whole business operation efficiency is low. Finally, thus using SLP to solve those problems, and put forward the company store aisle warehouse layout optimization strategy of management according to the comprehensive relations preliminary to the data warehouse layout optimization figure.