•Water absorption of FRP included a Fick's diffusion and deterioration responses.•Linear relationship between mechanical properties and bonding water was established.•Mechanical properties decreased owing to resin plasticization and interface debonding.•Long-term life prediction was conducted to provide an application guideline of FRP. The hygrothermal aging of fiber reinforced polymer (FRP) composite rod served as bridge cables played a key role on the long-term service performances. In the present paper, two types of pultruded carbon/glass fiber reinforced epoxy hybrid composite rods, one with uniformly dispersed carbon and glass fibers, and the other with glass fiber shell and carbon fiber core, were investigated on the water uptake and interface shear strength. The aging condition was immersion in deionized water at 40 °C, 60 °C and 80 °C. Interface shear strength degradation mechanism was revealed by thermal analysis and microstructure analysis. It was found that the water absorption of two types of hybrid rods represented the two-stage behavior. For the rod of uniform fiber dispersion, more water uptake in the second stage occurred compared to that of the shell/core rod, which was attributed to the resin rich area and interface debonding of fiber/resin. Long-term hygrothermal exposure led to a remarkable degradation in the interfacial shear strength of the rods, up to 17.5% ∼ 42.1%. The resin plasticization and interface debonding were the main factors contributed to the strength degradation. Based on the Arrhenius equation, the long-term life prediction of the interfacial shear strength under two typical bridge service environments was conducted to the design guideline of hybrid rods in the bridge engineering.