The present study deals with the development of hydroxyapatite (HAp)-ciprofloxacin bone-implants using the »Quality by design« approach. The effect of various synthesis parameters like drug amount added in the process, stirring speed and addition rate of orthophosphoric acid in the synthesis on drug concentration in the HAp-ciprofloxacin system synthesized by the precipitation technique using 23 factorial design was analyzed. Optimization methodology utillizing the first-order polynomial equation was used to search for optimal drug concentration in the HAp-ciprofloxacin implant system. The observed responses coincided well with the predicted values from the optimization technique. New implants were manufactured using various HAp-ciprofloxacin composites and 1.5 % (m/V) guar gum as a binder. Characterization of the delivery system was done by XRPD, FTIR spectroscopy and SEM. Even at highest drug concentration (76.6 ± 0.5 %, m/m), ciprofloxacin was present in noncrystalline state. The in vitro ciprofloxacin release from various bone-implants was sustained for several weeks and the drug release pattern correlated well with the Korsmeyer- Peppas model. U radu je opisan razvoj hidroksiapatit (HAp)-ciprofloksacin implantata za kosti »dizajniranjem kvalitete«. Učinak nezavisnih varijabli poput količine dodanog lijeka, brzine miješanja i udjela ortofosforne kiseline na koncentraciju lijeka u HAp-sustavu dobivenom precipitacijom optimiran je koristeći 23 faktorijalno dizajniranje. Pomoću polinomske jednadžbe prvog reda određena je optimalna koncentracija lijeka u implantatima na bazi HAp. Dobiveni odgovori podudaraju se s predviđenim vrijednostima iz optimiranih formulacija. Novi implantati pripravljeni su koristeći različite omjere HAp i ciprofloksacina te 1,5 % (m/V) guar gumu kao vezivo. Karakterizacija sustava za isporuku provedena je pomoću XRPD, FTIR spektroskopije i SEM. Ciprofloksacin je prisutan u amorfnom stanju čak pri najvišim koncentracijama (76,6 ± 0,5 %, m/m). In vitro oslobađanje ciprofloksacina iz različitih implantata bilo je polagano tijekom nekoliko tjedana i dobro je koreliralo s Korsmeyer-Peppasovim modelom.