E-viri
Recenzirano
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Bao, Deng-Hui; Wu, Hui-Ling; Liu, Chao-Lun; Xie, Jian-Hua; Zhou, Qi-Lin
Angewandte Chemie (International ed.), July 20, 2015, Letnik: 54, Številka: 30Journal Article
The chiral tridentate spiro P‐N‐S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3‐dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of β‐alkyl‐β‐ketoesters, producing chiral β‐alkyl‐β‐hydroxyesters with excellent enantioselectivities (95–99.9 % ee) and turnover numbers of up to 355 000. Bulkyness is the key: New chiral tridentate spiro P‐N‐S ligands (SpiroSAP) bearing a conformationally constrained 1,3‐dithiane moiety were developed. Their iridium catalysts showed excellent enantioselectivities and activity (TON up to 355 000) for asymmetric hydrogenation of β‐alkyl‐β‐ketoesters.
